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Charlotte Warren-Gash 1 Article
Data resource profile: the National Health Insurance Research Database (NHIRD)
Liang-yu Lin, Charlotte Warren-Gash, Liam Smeeth, Pau-Chung Chen
Epidemiol Health. 2018;40:e2018062.   Published online December 27, 2018
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AbstractAbstract PDFSupplementary Material
Electronic health records (EHRs) can provide researchers with extraordinary opportunities for population-based research. The National Health Insurance system of Taiwan was established in 1995 and covers more than 99.6% of the Taiwanese population; this system’s claims data are released as the National Health Insurance Research Database (NHIRD). All data from primary outpatient departments and inpatient hospital care settings after 2000 are included in this database. After a change and update in 2016, the NHIRD is maintained and regulated by the Data Science Centre of the Ministry of Health and Welfare of Taiwan. Datasets for approved research are released in three forms: sampling datasets comprising 2 million subjects, disease-specific databases, and full population datasets. These datasets are de-identified and contain basic demographic information, disease diagnoses, prescriptions, operations, and investigations. Data can be linked to government surveys or other research datasets. While only a small number of validation studies with small sample sizes have been undertaken, they have generally reported positive predictive values of over 70% for various diagnoses. Currently, patients cannot opt out of inclusion in the database, although this requirement is under review. In conclusion, the NHIRD is a large, powerful data source for biomedical research.


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    Environmental Research Letters.2020; 15(9): 094058.     CrossRef
  • Liver cancer prediction in a viral hepatitis cohort: A deep learning approach
    Dinh‐Van Phan, Chien‐Lung Chan, Ai‐Hsien Adams Li, Ting‐Ying Chien, Van‐Chuc Nguyen
    International Journal of Cancer.2020; 147(10): 2871.     CrossRef
  • Medical Insurance Information Systems in China: Mixed Methods Study
    Yazi Li, Chunji Lu, Yang Liu
    JMIR Medical Informatics.2020; 8(9): e18780.     CrossRef
  • Impact of tonsillectomy on irritable bowel syndrome: A nationwide population-based cohort study
    Meng-Che Wu, Kevin Sheng-Kai Ma, Yu-Hsun Wang, James Cheng-Chung Wei, Sanjiv Mahadeva
    PLOS ONE.2020; 15(9): e0238242.     CrossRef
  • Challenges faced in managing adult asthma: A perspective from Asian countries
    Raja Dhar, Mary Ip, Tarang Kulkarni, Sang‐Heon Kim, Diahn‐Warng Perng, Xin Yao, Takashi Iwanaga, Mariko Siyue Koh
    Respirology.2020; 25(12): 1235.     CrossRef
  • Impact of Liver Cirrhosis on Incidence of Dialysis Among Patients with Type 2 Diabetes
    Yi-Jing Sheen, Pei-Tseng Kung, Wayne H.-H. Sheu, Wei-Yin Kuo, Wen-Chen Tsai
    Diabetes Therapy.2020; 11(11): 2611.     CrossRef
  • Association of Infections and Use of Fluoroquinolones With the Risk of Aortic Aneurysm or Aortic Dissection
    Yaa-Hui Dong, Chia-Hsuin Chang, Jiun-Ling Wang, Li-Chiu Wu, Jou-Wei Lin, Sengwee Toh
    JAMA Internal Medicine.2020; 180(12): 1587.     CrossRef
  • Association of ocular diseases with schizophrenia, bipolar disorder, and major depressive disorder: a retrospective case-control, population-based study
    Chun-Hao Liu, Eugene Yu-Chuan Kang, Yu-Hsiang Lin, Wei-Chi Wu, Zhuo-Hao Liu, Chang-Fu Kuo, Chi-Chun Lai, Yih-Shiou Hwang
    BMC Psychiatry.2020;[Epub]     CrossRef
  • Constipation might be associated with risk of allergic rhinitis: A nationwide population-based cohort study
    Meng-Che Wu, Ming-Shiou Jan, Jeng-Yuan Chiou, Yu-Hsun Wang, James Cheng-Chung Wei, Tomohiko Ai
    PLOS ONE.2020; 15(10): e0239723.     CrossRef
  • Economic burden of cancers in Taiwan: a direct and indirect cost estimate for 2007–2017
    Shao-Yi Huang, Ho-Min Chen, Kai-Hsin Liao, Bor-Sheng Ko, Fei-Yuan Hsiao
    BMJ Open.2020; 10(10): e036341.     CrossRef
  • Uremic pruritus and long-term morbidities in the dialysis population
    Sze-Wen Ting, Pei-Chun Fan, Yu-Sheng Lin, Ming-Shyan Lin, Cheng-Chia Lee, George Kuo, Chih-Hsiang Chang, Yu Ru Kou
    PLOS ONE.2020; 15(10): e0241088.     CrossRef
  • Clinical Use of Acid Suppressants and Risk of Dementia in the Elderly: A Pharmaco-Epidemiological Cohort Study
    Liang-Yu Chen, Huey-Juan Lin, Wen-Tung Wu, Yong-Chen Chen, Cheng-Li Chen, Jing Kao, San-Lin You, Yu-Ching Chou, Chien-An Sun
    International Journal of Environmental Research and Public Health.2020; 17(21): 8271.     CrossRef
  • Association Between Low-Dose Aspirin Use and Colorectal Cancer Incidence in Taiwan
    Hui-Min Diana Lin, Pareen Vora, Montse Soriano-Gabarró, K. Arnold Chan
    JAMA Network Open.2020; 3(11): e2026494.     CrossRef
  • Effects of Erythropoietin Payment Policy on Cardiovascular Outcomes of Peritoneal Dialysis Patients: Observational Study
    Ying-Hui Hou, Feng-Jung Yang, I-Chun Lai, Shih-Pi Lin, Thomas TH Wan, Ray-E Chang
    JMIR Medical Informatics.2020; 8(12): e18716.     CrossRef
  • Hysterectomies are associated with an increased risk of osteoporosis and bone fracture: A population-based cohort study
    Ying-Ting Yeh, Pei-Chen Li, Kun-Chi Wu, Yu-Cih Yang, Weishan Chen, Hei-Tung Yip, Jen-Hung Wang, Shinn-Zong Lin, Dah-Ching Ding, Yu Ru Kou
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  • Outcomes after surgery in patients with diabetes who used metformin: a retrospective cohort study based on a real-world database
    Chao-Shun Lin, Chuen-Chau Chang, Chun-Chieh Yeh, Yi-Cheng Chang, Ta-Liang Chen, Chien-Chang Liao
    BMJ Open Diabetes Research & Care.2020; 8(2): e001351.     CrossRef
  • Risk of Leukemia after Dengue Virus Infection: A Population-Based Cohort Study
    Yu-Wen Chien, Chia-Chun Wang, Yu-Ping Wang, Cho-Yin Lee, Guey Chuen Perng
    Cancer Epidemiology, Biomarkers & Prevention.2020; 29(3): 558.     CrossRef
  • Big Data in Ophthalmology
    Ching-Yu Cheng, Zhi Da Soh, Shivani Majithia, Sahil Thakur, Tyler Hyungtaek Rim, Yih Chung Tham, Tien Yin Wong
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  • Apolipoprotein B Level and the Apolipoprotein B/Apolipoprotein A-I Ratio as a Harbinger of Ischemic Stroke: A Prospective Observation in Taiwan
    Yu-Ching Chou, Po-Chi Chan, Tsan Yang, San-Lin You, Chyi-Huey Bai, Chien-An Sun
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  • Risk of Dementia in Diabetic Patients with Hyperglycemic Crisis: A Nationwide Taiwanese Population-Based Cohort Study
    Chih-Ho Chou, I-Jung Feng, Yi-Chen Chen, Jiann-Hwa Chen, Hung-Jung Lin, Jhi-Joung Wang, Chien-Chin Hsu, Chien-Cheng Huang
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  • Incidence and risk of major adverse cardiovascular events in middle-aged patients with chronic kidney disease: a population-based cohort study
    Shiauyee Chen, Wen-yen Hsu, Yen-Nung Lin, Chien-Yung Wang, Chien-Hua Wu, Kwang-Hwa Chang
    International Urology and Nephrology.2019; 51(7): 1219.     CrossRef
  • Dental treatment procedures for periodontal disease and the subsequent risk of ischaemic stroke: A retrospective population‐based cohort study
    Hsiao‐Wei Lin, Chun‐Min Chen, Yi‐Chun Yeh, Yen‐Yu Chen, Ru‐Yu Guo, Yen‐Ping Lin, Ya‐Ching Li
    Journal of Clinical Periodontology.2019; 46(6): 642.     CrossRef
  • Risk of schizophrenia among people with obsessive-compulsive disorder: A nationwide population-based cohort study
    Yu-Fang Cheng, Vincent Chin-Hung Chen, Yao-Hsu Yang, Ko-Jung Chen, Yi-Chen Lee, Mong-Liang Lu
    Schizophrenia Research.2019; 209: 58.     CrossRef
  • Use of Antiplatelet Agents and Survival of Tuberculosis Patients: A Population-Based Cohort Study
    Meng-Rui Lee, Ming-Chia Lee, Chia-Hao Chang, Chia-Jung Liu, Lih-Yu Chang, Jun-Fu Zhang, Jann-Yuan Wang, Chih-Hsin Lee
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  • Statin use and Vital Organ Failure in Patients With Asthma–Chronic Obstructive Pulmonary Disease Overlap: A Time-Dependent Population-Based Study
    Jun-Jun Yeh, Shih-Huei Syue, Cheng-Li Lin, Chung Y. Hsu, Zonyin Shae, Chia-Hung Kao
    Frontiers in Pharmacology.2019;[Epub]     CrossRef
  • Health care utilization pattern prior to maltreatment among children under five years of age in Taiwan
    Liang-Yi Wang, Chih-Ying Wu, Yi-Hsin Chang, Tsung-Hsueh Lu
    Child Abuse & Neglect.2019; 98: 104202.     CrossRef
  • Insulin enhances and metformin reduces risk of colorectal carcinoma in type-2 diabetes
    C-H Chen, C-L Lin, C-Y Hsu, C-H Kao
    QJM: An International Journal of Medicine.2019;[Epub]     CrossRef
  • Association of gout medications and risk of cataract: a population-based case–control study
    Y-J Li, W-T Perng, K-Y Tseng, Y-H Wang, J C-C Wei
    QJM: An International Journal of Medicine.2019; 112(11): 841.     CrossRef
  • High risk of gastrointestinal hemorrhage in patients with systemic sclerosis
    Yi-Ting Lin, Yun-Shiuan Chuang, Jiunn-Wei Wang, Ping-Hsun Wu
    Arthritis Research & Therapy.2019;[Epub]     CrossRef
  • Herbal Medicine Containing Aristolochic Acid and the Risk of Primary Liver Cancer in Patients with Hepatitis C Virus Infection
    Chi-Jen Chen, Yao-Hsu Yang, Meng-Hung Lin, Chuan-Pin Lee, Yu-Tse Tsan, Ming-Nan Lai, Hsiao-Yu Yang, Pat Doyle, Wen-Chao Ho, Pau-Chung Chen
    Cancer Epidemiology, Biomarkers & Prevention.2019; 28(11): 1876.     CrossRef

Epidemiol Health : Epidemiology and Health