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Predictors of miscarriage: a matched case-control study
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Jalal Poorolajal, Parvin Cheraghi, Zahra Cheraghi, Masoomeh Ghahramani, Amin Doosti Irani
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Epidemiol Health. 2014;36:e2014031. Published online November 20, 2014
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DOI: https://doi.org/10.4178/epih/e2014031
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Abstract
OBJECTIVES
The risk factors for miscarriage vary across communities and countries. This study was conducted to investigate the predictors of miscarriage in the west of Iran.
METHODS This matched case-control study was conducted in Hamadan Province from April 2013 to March 2014. Cases were selected from women who had a recent spontaneous abortion and controls were selected from women who had a recent live birth. Two controls were selected for every case and matched for date of pregnancy and area of residence. Multivariate conditional logistic regression analysis was performed and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
RESULTS Five hundred fifty cases were compared with 1,091 controls. The OR of miscarriage was 1.58 (95% CI=1.30-1.92) for every five-year increase in age, 0.20 (95% CI=0.14-0.28) for every live birth, and 3.43 (95% CI=2.03-5.79) for a history of previous spontaneous abortion. Compared to nulliparous women, primiparous or multiparous women had an OR of 17.85 (95% CI=6.65-47.91) for miscarriage. There was a strong association between miscarriage and abnormal amniotic status (OR, 2.46; 95% CI, 0.46-13.09) and also abnormal placenta status (OR, 10.44; 95% CI, 0.95-114.92); however, these associations were not statistically significant. No significant associations were observed between miscarriage and body mass index, previous history of stillbirth, low birth weight, congenital anomaly, ectopic pregnancy, impaired thyroid function, or high blood pressure.
CONCLUSIONS Our study suggests that miscarriage is a multifactorial outcome associated with several modifiable and non-modifiable risk factors that may vary among different communities.
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Summary
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Citations
Citations to this article as recorded by  - Understanding Miscarriage Prevalence and Risk Factors: Insights from Women in Jordan
Zina Al-Alami, Rana Abu-Huwaij, Shereen Hamadneh, Esra’ Taybeh
Medicina.2024; 60(7): 1044. CrossRef - Gestational lead exposure and its effects on fetal/infant development - A systematic review
Aleksander Brandão Santana, Lídia Emmanuela Wiazowski Spelta, Joselin Valeska Martinez Sobalvarro, Márcia Helena Miranda Cardoso Podestá, Raphael Caio Tamborelli Garcia, Tiago Marques dos Reis, Larissa Helena Torres
Reproductive Toxicology.2023; 117: 108342. CrossRef - Pembangunan dan Pengesahan Instrumen Pengetahuan, Sikap dan Penghayatan Terhadap Unsur Tradisi Dalam Perlembagaan Persekutuan
Khadijah Muda, Siti Nor Azhani Mohd Tohar, Khairul Anwar Johari Mastor, Nazri Muslim, Fazilah Idris, Siti Nor Baya Yacob
Pertanika Journal of Social Sciences and Humanities.2023; 31(1): 183. CrossRef - A Validation Study on the Frequency and Natural History of Miscarriages Using the Spanish Primary Care Database BIFAP
Sara Sanchez Ortiz, Consuelo Huerta, Ana Llorente-García, Paloma Ortega, Paloma Astasio, Lucía Cea-Soriano
Healthcare.2021; 9(5): 596. CrossRef - Cytogenetic Analysis of Spontaneous Miscarriages Using Long-Term Culturing of Chorionic Villi
Isao Horiuchi, Yu Wakimoto, Tomoyuki Kuwata, Hideaki Sawai, Hiroaki Shibahara, Kenjiro Takagi
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Elizabeth Pontius, Julie T. Vieth
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Hai-Yan Wang, Jie Qiao, Xiao-Xi Sun, Shu-Yu Wang, Xiao-Yan Liang, Yun Sun, Feng-Hua Liu
Chinese Medical Journal.2017; 130(17): 2056. CrossRef - Maternal pre-pregnancy risk factors for miscarriage from a prevention perspective: a cohort study in China
Huan Zhou, Yongping Liu, Lu Liu, Min Zhang, Xingzhi Chen, Yulong Qi
European Journal of Obstetrics & Gynecology and Reproductive Biology.2016; 206: 57. CrossRef - Systematic review and meta-analysis on the association of prepregnancy underweight and miscarriage
Montserrat Balsells, Apolonia García-Patterson, Rosa Corcoy
European Journal of Obstetrics & Gynecology and Reproductive Biology.2016; 207: 73. CrossRef - Fasting blood glucose and newborn birth weight of non- diabetic Sudanese women
Abdelmageed Elmugabil, Duria A. Rayis, Ishag Adam, Mohamed F. Lutfi
F1000Research.2016; 5: 641. CrossRef
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Risk factors for maternal mortality in the west of Iran: a nested case-control study
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Jalal Poorolajal, Behnaz Alafchi, Roya Najafi Vosoogh, Sahar Hamzeh, Masoomeh Ghahramani
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Epidemiol Health. 2014;36:e2014028. Published online November 8, 2014
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DOI: https://doi.org/10.4178/epih/e2014028
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19,154
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147
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7
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Abstract
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Abstract
OBJECTIVES
With a gradual decline in maternal mortality in recent years in Iran, this study was conducted to identify the remaining risk factors for maternal death.
METHODS This 8-year nested case-control study was conducted in Hamadan Province, in the west of Iran, from April 2006 to March 2014. It included 185 women (37 cases and 148 controls). All maternal deaths that occurred during the study period were considered cases. For every case, four women with a live birth were selected as controls from the same area and date. Conditional logistic regression analysis was performed and the odds ratio (OR) and its 95% confidence interval (CI) were obtained for each risk factor.
RESULTS The majority of cases were aged 20-34 years, died in hospital, and lived in urban areas. The most common causes of death were bleeding, systemic disease, infection, and pre-eclampsia. The OR estimate of maternal death was 8.48 (95% CI=1.26-56.99) for advanced maternal age (≥35 years); 2.10 (95% CI=0.07-65.43) for underweight and 10.99 (95% CI=1.65-73.22) for overweight or obese women compared to those with normal weight; 1.56 (95% CI=1.08-2.25) for every unit increase in gravidity compared to those with one gravidity; 1.73 (95% CI=0.34-8.88) for preterm labors compared to term labors; and 17.54 (95% CI= 2.71-113.42) for women with systemic diseases.
CONCLUSIONS According to our results, advanced maternal age, abnormal body mass index, multiple gravidity, preterm labor, and systemic disease were the main risk factors for maternal death. However, more evidence based on large cohort studies in different settings is required to confirm our results.
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Summary
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Citations
Citations to this article as recorded by - A retrospective descriptive study of NANDA‐I nursing diagnoses used by midwives working in obstetrics and gynecologic service: An example from south‐eastern Turkey
Yeşim Yeşil, Leyla Baran
International Journal of Nursing Knowledge.2024; 35(2): 163. CrossRef - Epidemiological and Maternal Features of Maternal Mortality in the West
of Iran: Hamadan, 2011-2019
Azam Ali Shirzad, Ebrahim Jalili , Fatemeh Shahbazi, Hasan Bahrami, Salman Khazaei, Samereh Ghelichkhani
Current Women s Health Reviews.2022;[Epub] CrossRef - A systematic review of individual and ecological determinants of maternal mortality in the world based on the income level of countries
Maryam Tajvar, Alireza Hajizadeh, Rostam Zalvand
BMC Public Health.2022;[Epub] CrossRef - Determinants and causes of maternal mortality in Iran based on ICD-MM: a systematic review
Rostam Zalvand, Maryam Tajvar, Abolghasem Pourreza, Hadi Asheghi
Reproductive Health.2019;[Epub] CrossRef - Evaluation of Satisfaction with Natural Delivery Experience and its Related Factors in Rasht Women
Mona Ghobadi, Tahereh Ziaee, Noshaz Mirhaghjo, Farzaneh Pazandeh, Ehsan Kazemnejad lili
Journal of Health and Care.2018; 20(3): 215. CrossRef - Predictors and measurement of satisfaction with postpartum care in a government hospital
Simge Zeyneloğlu, Sezer Kısa, Hülya Özberk, Aysun Badem
Nursing & Health Sciences.2017; 19(2): 198. CrossRef
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