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Mohammadhossein Rahimi Rad 1 Article
Effects of antibiotic consumption on children 2-8 years of age developing asthma
Hamid Reza Khalkhali, Sima Oshnouei, Shaker Salarilak, Mohammadhossein Rahimi Rad, Mohammad Karamyar, Javad Khashabi
Epidemiol Health. 2014;36:e2014006.   Published online July 4, 2014
DOI: https://doi.org/10.4178/epih/e2014006
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  • 13 Web of Science
  • 13 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
Antibiotic exposure in children is a possible contributor to the increasing asthma prevalence in several countries. The present study aimed to investigate the association between antibiotic exposure and the risk of developing childhood asthma at 2-8 years of age.
METHODS
A case-control study was undertaken among children aged 2-8 years old between March and September 2010 in the Urmia district in the northwest of Iran. The cases were doctor-diagnosed asthmatic children based on Global Initiative for Asthma criteria (n=207), and the controls were children without respiratory symptoms (n=400) selected by frequency matching by age and gender. Clinical data including antibiotic exposure was collected by a validated and reliable questionnaire, which was completed by interviewing parents/guardians.
RESULTS
Antibiotic consumption during the first year of life increased the odds ratio [OR] of asthma symptoms at 2-8 years of age (crude OR, 2.26; 95% confidence interval [CI], 1.53-3.35; p<0.01), and the strength of association was similar after adjusting for a family history of asthma or atopic disorder, preterm delivery, birth order, and delivery method (adjusted OR, 1.91; 95% CI, 1.27-2.88; p=0.03).
CONCLUSIONS
Our study suggests that antibiotic consumption in children was associated with an increased risk of childhood asthma, and an additional confirmative study is needed.
Summary

Citations

Citations to this article as recorded by  
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    Chest.2020; 157(2): 334.     CrossRef
  • The relationship of prenatal antibiotic exposure and infant antibiotic administration with childhood allergies: a systematic review
    Ruth Baron, Meron Taye, Isolde Besseling-van der Vaart, Joanne Ujčič-Voortman, Hania Szajewska, Jacob C. Seidell, Arnoud Verhoeff
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  • Respiratory morbidity, atopy and asthma at school age in preterm infants aged 32–35 weeks
    Júlia Morata-Alba, Maria Teresa Romero-Rubio, Silvia Castillo-Corullón, Amparo Escribano-Montaner
    European Journal of Pediatrics.2019; 178(7): 973.     CrossRef
  • Evaluation of Allergic Symptoms Prevalence and Its Relationship with Acetaminophen/Antibiotic Use and Hospitalization Among School-Aged Children in Tehran, Iran
    Mohammad Reza Fazlollahi, Javid Morad Abbasi, Vahid Ghobadi Dana, Alireza Yousefzade, Nastaran Sabetkish, Shahpar Haghighat
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  • Airway Microbiota and the Implications of Dysbiosis in Asthma
    Juliana Durack, Homer A. Boushey, Susan V. Lynch
    Current Allergy and Asthma Reports.2016;[Epub]     CrossRef
  • Early-life antibiotic use is associated with wheezing among children with high atopic risk: a prospective European study
    Wenjie Sun, Erik R. Svendsen, Wilfried J. J. Karmaus, Joachim Kuehr, Johannes Forster
    Journal of Asthma.2015; 52(7): 647.     CrossRef

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