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Yuandi Xi 1 Article
Exploring cognitive trajectories and their association with physical performance: evidence from the China Health and Retirement Longitudinal Study
Jingdong Suo, Xianlei Shen, Jinyu He, Haoran Sun, Yu Shi, Rongxin He, Xiao Zhang, Xijie Wang, Yuandi Xi, Wannian Liang
Epidemiol Health. 2023;45:e2023064.   Published online July 9, 2023
DOI: https://doi.org/10.4178/epih.e2023064
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AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
The long-term trends of cognitive function and its associations with physical performance remain unclear, particularly in Asian populations. The study objectives were to determine cognitive trajectories in middle-aged and elderly Chinese individuals, as well as to examine differences in physical performance across cognitive trajectory groups.
METHODS
Data were extracted from the China Health and Retirement Longitudinal Study. A total of 5,701 participants (47.7% male) with a mean age of 57.8 (standard deviation, 8.4) years at enrollment were included. A group-based trajectory model was used to identify cognitive trajectory groups for each sex. Grip strength, repeated chair stand, and standing balance tests were used to evaluate physical performance. An ordered logistic regression model was employed to analyze differences in physical performance across cognitive trajectory groups.
RESULTS
Three cognitive trajectory groups were identified for each sex: low, middle, and high. For both sexes, higher cognitive trajectory groups exhibited smaller declines with age. In the fully adjusted model, relative to the low trajectory group, the odds ratios (ORs) of better physical performance in the middle cognitive group were 1.37 (95% confidence interval [CI], 1.17 to 1.59; p<0.001) during follow-up and 1.40 (95% CI, 1.20 to 1.64; p<0.001) at the endpoint. The ORs in the high trajectory group were 1.94 (95% CI, 1.61 to 2.32; p<0.001) during follow-up and 2.04 (95% CI, 1.69 to 2.45; p<0.001) at the endpoint.
CONCLUSIONS
Cognitive function was better preserved in male participants and individuals with higher baseline cognitive function. A higher cognitive trajectory was associated with better physical performance over time.
Summary
Key Message
Three cognitive trajectory groups were identified for each sex in middle-aged and elderly Chinese people. Cognitive function was found to be better preserved in male participants and individuals with higher baseline cognitive function. Better cognitive trajectory was associated with better physical performance over time.

Citations

Citations to this article as recorded by  
  • Longitudinal trajectories of cognitive aging
    Elena Lobo, Patricia Gracia-GarcĂ­a, Antonio Lobo
    Current Opinion in Psychiatry.2024; 37(2): 123.     CrossRef
  • Mediation role of DNA methylation in association between handgrip strength and cognitive function in monozygotic twins
    Jin Liu, Weijing Wang, Jia Luo, Haiping Duan, Chunsheng Xu, Xiaocao Tian, Shumin Chen, Lin Ge, Dongfeng Zhang
    Journal of Human Genetics.2024;[Epub]     CrossRef

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