Skip Navigation
Skip to contents

Epidemiol Health : Epidemiology and Health



Page Path
HOME > Search
1 "Restricted cubic spline"
Article category
Publication year
Dose-response meta-analysis: application and practice using the R software
Sung Ryul Shim, Jonghoo Lee
Epidemiol Health. 2019;41:e2019006.   Published online March 28, 2019
  • 19,130 View
  • 565 Download
  • 46 Web of Science
  • 38 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
The objective of this study was to describe the general approaches of dose-response meta-analysis (DRMA) available for the quantitative synthesis of data using the R software. We conducted a DRMA using two types of data, the difference of means in continuous data and the odds ratio in binary data. The package commands of the R software were “doseresmeta” for the overall effect sizes that were separated into a linear model, quadratic model, and restricted cubic split model for better understanding. The effect sizes according to the dose and a test for linearity were demonstrated and interpreted by analyzing one-stage and two-stage DRMA. The authors examined several flexible models of exposure to pool study-specific trends and made a graphical presentation of the dose-response trend. This study focused on practical methods of DRMA rather than theoretical concepts for researchers who did not major in statistics. The authors hope that this study will help many researchers use the R software to perform DRMAs more easily, and that related research will be pursued.
Korean summary
통계프로그램으로서의 R이 대세인 연구환경에서 R을 활용한 체계적인 메타분석 안내서가 요구되어지며 본 연구는 이에 대한 좋은 해답이 될 것이다. 더욱이 본 연구는 용량-반응 메타분석 (Dose-response meta-analysis)의 이론과 더불어 R을 활용한 실습위주의 내용으로 구성되어져 있어 누구나 쉽게 실행할 수 있을 것이다. 본 연구를 통하여 많은 연구자들이 보다 쉽게 본인의 연구분야에 적용하여 관련 연구가 활성화되기를 바란다.


Citations to this article as recorded by  
  • Associations of obesity indices change with cardiovascular outcomes: a dose-response meta-analysis
    Lyu Wang, Hanyue Ding, Yunyang Deng, Junjie Huang, Xiangqian Lao, Martin C. S. Wong
    International Journal of Obesity.2024; 48(5): 635.     CrossRef
  • The Best Exercise Modality and Dose for Reducing Pain in Adults With Low Back Pain: A Systematic Review With Model-Based Bayesian Network Meta-analysis
    Zhide Liang, Shudong Tian, Chuanzhi Wang, Meng Zhang, Hengzhi Guo, Yingdanni Yu, Xianliang Wang
    Journal of Orthopaedic & Sports Physical Therapy.2024; 54(5): 315.     CrossRef
  • The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose–response meta-analysis
    Seung Wan Suh, Eunji Lim, Suh-Yuhn Burm, Hyungji Lee, Jong Bin Bae, Ji Won Han, Ki Woong Kim
    BMC Medicine.2024;[Epub]     CrossRef
  • Alcohol consumption and its correlation with medical conditions: a UK Biobank study
    Craig S. Mayer, Paul Fontelo
    Frontiers in Public Health.2024;[Epub]     CrossRef
  • REDOMA: Bayesian random‐effects dose‐optimization meta‐analysis using spike‐and‐slab priors
    Cheng‐Han Yang, Evan Kwiatkowski, J. Jack Lee, Ruitao Lin
    Statistics in Medicine.2024;[Epub]     CrossRef
  • Nonlinear relationship between serum 25-hydroxyvitamin D and lipid profile in Chinese adults
    Qianqian Wang, Xinlei Miao, Manling Hu, Fei Xu, Guimin Tang, Yangxuan He, Ziping Song, Wan Zhao, Xiangjun Niu, Song Leng
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • The Best Exercise Modality and Dose to Reduce Glycosylated Hemoglobin in Patients with Type 2 Diabetes: A Systematic Review with Pairwise, Network, and Dose–Response Meta-Analyses
    Zhide Liang, Meng Zhang, Chuanzhi Wang, Fengwei Hao, Yingdanni Yu, Shudong Tian, Yang Yuan
    Sports Medicine.2024;[Epub]     CrossRef
  • Vortioxetine for depression in adults: A systematic review and dose–response meta‐analysis of randomized controlled trials
    Xin Yang, Shuping Fang, Wenqi Lyu, Yongbo Hu, Huifang Xu, Xiao Jiang, Yurou Zhao, Yuwei Zhang, Jin Li, Weihong Kuang
    Psychiatry and Clinical Neurosciences.2024;[Epub]     CrossRef
  • Association of birth weight with cancer risk: a dose–response meta-analysis and Mendelian randomization study
    Chao Chen, Xiaoying Chen, Donghong Wu, Huiting Wang, Chuqiao Wang, Jieni Shen, Yiran An, Ran Zhong, Caichen Li, Wenhua Liang
    Journal of Cancer Research and Clinical Oncology.2023; 149(7): 3925.     CrossRef
  • Protocol for a systematic review and meta-analysis on preoperative risk factors for failure after fixed sling implantation for post-prostatectomy stress urinary incontinence
    Emilio Sacco, Filippo Marino, Filippo Gavi, Stefano Moretto, Carlo Gandi, Riccardo Bientinesi, Francesco Pierconti, Pierfrancesco Bassi
    F1000Research.2023; 12: 19.     CrossRef
  • Does paternal age affect the live birth rate in donor oocyte cycles? A systematic review and meta-analysis
    Emmanuelle Begon, Tiphaine Lefebvre, Elisangela Arbo, Sarah Bouée, Bernadette Darné, Frédérique Jaffré, Solène Languille, Dikra Mellouhi, Jean-Christophe Pont, Noémie Rousset, Thomas Fréour
    Journal of Assisted Reproduction and Genetics.2023; 40(3): 617.     CrossRef
  • The Association between Prenatal Per- and Polyfluoroalkyl Substances Exposure and Neurobehavioral Problems in Offspring: A Meta-Analysis
    Huojie Yao, Yingyin Fu, Xueqiong Weng, Zurui Zeng, Yuxuan Tan, Xiaomei Wu, Huixian Zeng, Zhiyu Yang, Yexin Li, Huanzhu Liang, Yingying Wu, Lin Wen, Chunxia Jing
    International Journal of Environmental Research and Public Health.2023; 20(3): 1668.     CrossRef
  • Seizure risk in multiple sclerosis patients treated with disease-modifying therapy: A systematic review and network meta-analysis
    Yew Li Dang, Vivien TY Yong, Sifat Sharmin, Piero Perucca, Tomas Kalincik
    Multiple Sclerosis Journal.2023; 29(6): 657.     CrossRef
  • Hyponatremia and mortality in patients undergoing maintenance hemodialysis: Systematic review and meta‐analysis
    Takamasa Miyauchi, Hiroki Nishiwaki, Aya Mizukami, Masahiko Yazawa
    Seminars in Dialysis.2023; 36(4): 303.     CrossRef
  • Effect of olive oil phenols on oxidative stress biomarkers: A systematic review and dose–response meta‐analysis of randomized clinical trials
    Seyedeh‐Masomeh Derakhshandeh‐Rishehri, Asma Kazemi, Sung Ryul Shim, Mostafa Lotfi, Shabnam Mohabati, Mehran Nouri, Shiva Faghih
    Food Science & Nutrition.2023; 11(5): 2393.     CrossRef
  • Dose–Response Meta-Analysis of Corticosteroid Effects in SARS Outbreak: A Model for Risk Stratification and Screening Strategy for Osteonecrosis of Femoral Head Post-Corticosteroid Therapy for COVID-19
    Sathish Muthu, Madhan Jeyaraman, Preethi Selvaraj, Naveen Jeyaraman, Anish Potty, Ashim Gupta
    Life.2023; 13(4): 907.     CrossRef
  • Vitamin D status and cognitive performance in community-dwelling adults: A dose-response meta-analysis of observational studies
    Janis D. Harse, Ross J. Marriott, Kun Zhu, Kevin Murray, Romola S. Bucks
    Frontiers in Neuroendocrinology.2023; 70: 101080.     CrossRef
  • Association between adiposity after diagnosis of prostate cancer and mortality: systematic review and meta-analysis
    Margarita Cariolou, Georgios Markozannes, Nerea Becerra-Tomás, Rita Vieira, Katia Balducci, Dagfinn Aune, David C Muller, Doris S M Chan, Konstantinos K Tsilidis
    BMJ Medicine.2023; 2(1): e000339.     CrossRef
  • Using serum anti-Müllerian hormone levels to predict the chance of live birth after spontaneous or assisted conception: a systematic review and meta-analysis
    Maeliss Peigné, Valérie Bernard, Laura Dijols, Hélène Creux, Geoffroy Robin, Claude Hocké, Michaël Grynberg, Didier Dewailly, Charlotte Sonigo
    Human Reproduction.2023; 38(9): 1789.     CrossRef
  • The Weight-loss Effect of GLP-1RAs Glucagon-Like Peptide-1 Receptor Agonists in Non-diabetic Individuals with Overweight or Obesity: A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials
    Yupeng Liu, Binye Ruan, Huinan Jiang, Siyu Le, Yi Liu, Xuemei Ao, Yufeng Huang, Xudong Shi, Ru Xue, Xiaoyi Fu, Shuran Wang
    The American Journal of Clinical Nutrition.2023; 118(3): 614.     CrossRef
  • Type A aortic dissection: optimal annual case volume for surgery
    Michal J Kawczynski, Sander M J van Kuijk, Jules R Olsthoorn, Jos G Maessen, Suzanne Kats, Elham Bidar, Samuel Heuts
    European Heart Journal.2023; 44(41): 4357.     CrossRef
  • Adherence to Data-Driven Dietary Patterns and Lung Cancer Risk: A Systematic Review and Dose–Response Meta-Analysis
    Roberto Fabiani, Gianandrea La Porta, Laura Li Cavoli, Patrizia Rosignoli, Manuela Chiavarini
    Nutrients.2023; 15(20): 4406.     CrossRef
  • Protocol for a systematic review and meta-analysis on preoperative risk factors for failure after fixed sling implantation for post-prostatectomy stress urinary incontinence
    Emilio Sacco, Filippo Marino, Filippo Gavi, Stefano Moretto, Carlo Gandi, Riccardo Bientinesi, Francesco Pierconti, Pierfrancesco Bassi
    F1000Research.2023; 12: 19.     CrossRef
  • Physical activity and cancer risk: a dose‐response analysis for the Global Burden of Disease Study 2019
    Xiayao Diao, Yudong Ling, Yi Zeng, Yueqian Wu, Chao Guo, Yukai Jin, Xiaojiang Chen, Shoucheng Feng, Jianrong Guo, Chao Ding, Feiyu Diao, Zhicheng Du, Shanqing Li, Haibo Qiu
    Cancer Communications.2023; 43(11): 1229.     CrossRef
  • Electrical energy by electrode placement for cardioversion of atrial fibrillation: a systematic review and meta-analysis
    Nicklas Vinter, Mikkel Zacharias Bystrup Holst-Hansen, Søren Paaske Johnsen, Gregory Y H Lip, Lars Frost, Ludovic Trinquart
    Open Heart.2023; 10(2): e002456.     CrossRef
  • Cancer risk based on alcohol consumption levels: a comprehensive systematic review and meta-analysis
    Seunghee Jun, Hyunjin Park, Ui-Jeong Kim, Eun Jeong Choi, Hye Ah Lee, Bomi Park, Soon Young Lee, Sun Ha Jee, Hyesook Park
    Epidemiology and Health.2023; 45: e2023092.     CrossRef
  • Increasing awareness of HIV pre‐exposure prophylaxis (PrEP) and willingness to use HIV PrEP among men who have sex with men: a systematic review and meta‐analysis of global data
    Zhishan Sun, Qianfei Gu, Yifan Dai, Huachun Zou, Bruce Agins, Qiaosen Chen, Peiyang Li, Junchun Shen, Yi Yang, Hongbo Jiang
    Journal of the International AIDS Society.2022;[Epub]     CrossRef
  • Effects of thyroid dysfunction and thyroid stimulating hormone levels on the Atrial fibrillation risks: a systematic review and dose-response meta-analysis from cohort studies
    Min Huang, Shengyi Yang, Ge Ge, Hong Zhi, Lina Wang
    Endocrine Practice.2022;[Epub]     CrossRef
  • Paraben exposures and their interactions with ESR1/2 genetic polymorphisms on hypertension
    Shuang Zhou, Hao Lu, Xu Zhang, Xueting Shi, Shunli Jiang, Lin Wang, Qing Lu
    Environmental Research.2022; 213: 113651.     CrossRef
  • The changes of IgE levels in type 2 inflammatory diseases after treatment of dupilumab: a systematic review and meta-analysis
    Boyang Zhou, Jialin Dong, Surong Liang, Shuai Shang, Linfeng Li
    Expert Review of Clinical Pharmacology.2022; 15(10): 1233.     CrossRef
  • Is altitude a determinant of the health benefits of nature exposure? A systematic review and meta-analysis
    Eunsoo Kim, Sujin Park, Soojin Kim, Yeji Choi, Jae Hyoung Cho, Geonwoo Kim
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Vitamin E Intake and Risk of Prostate Cancer: A Meta-Analysis
    Wei Qi Loh, Jiyoung Youn, Wei Jie Seow
    Nutrients.2022; 15(1): 14.     CrossRef
  • Investigation of the Utility of Multivariate Meta-Analysis Methods in Estimating the Summary Dose Response Curve
    Melepurakkal Sadanandan Deepthy, Kalesh Mappilakudy Karun, Kotten Thazhath Harichandrakumar, Narayanapillai Sreekumaran Nair
    Journal of Research in Health Sciences.2022; 22(4): e00561.     CrossRef
  • Prediction of the Long-Term Effect of Iron on Methane Yield in an Anaerobic Membrane Bioreactor Using Bayesian Network Meta-Analysis
    Dawei Yu, Yushuai Liang, Rathmalgodagei Thejani Nilusha, Tharindu Ritigala, Yuansong Wei
    Membranes.2021; 11(2): 100.     CrossRef
  • The association between urate‐lowering therapies and treatment‐related adverse events, liver damage, and major adverse cardiovascular events (MACE): A network meta‐analysis of randomized trials
    Siliang Zhang, Qiming Xie, Shuqing Xie, Jianwei Chen, Qingyue Deng, Ling Zhong, Jing Guo, Yuan Yu
    Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy.2021; 41(9): 781.     CrossRef
  • Cancer Risk After Radioactive Iodine Treatment for Hyperthyroidism
    Sung Ryul Shim, Cari M. Kitahara, Eun Shil Cha, Seong-Jang Kim, Ye Jin Bang, Won Jin Lee
    JAMA Network Open.2021; 4(9): e2125072.     CrossRef
  • Association between exposure to artificial sources of ultraviolet radiation and ocular diseases: a systematic review protocol
    Polani Chandrasekar Rubeshkumar, Manickam Ponnaiah, Durgadoss Anandhi, Denny John
    JBI Evidence Synthesis.2020; 18(8): 1766.     CrossRef
  • Non-linear Relationship between Tacrolimus Blood Concentration and Acute Rejection After Kidney Transplantation: A Systematic Review and Dose-Response Meta-Analysis of Cohort Studies
    Saifu Yin, Turun Song, Xingxing Li, Hanyue Xu, Xueling Zhang, Yamei Jiang, Tao Lin
    Current Pharmaceutical Design.2019; 25(21): 2394.     CrossRef

Epidemiol Health : Epidemiology and Health