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Epidemiology and Health 2022;e2022037.
DOI: https://doi.org/10.4178/epih.e2022037    [Accepted] Published online Apr 5, 2022.
The Asenze Cohort Study in KwaZulu-Natal, South Africa: Protocol and Cohort Profile
Chris Desmond1  , Gabriella A Norwitz2  , Jane D Kvalsvig3  , Rachel S Gruver2  , Shuaib Kauchali4  , Kathryn G Watt1  , Nonhlanhla P Myeza1  , Adele Munsami1  , Leslie L Davidson2,5 
1Centre for Rural Health, University of KwaZulu-Natal, Durban, South Africa
2Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, United States
3Department of Public Health, University of KwaZulu-Natal, Durban, South Africa
4Maternal, Adolescent, and Child Health (MatCH) Institute, NPC, Durban, South Africa
5Department of Pediatrics Columbia College of Physicians and Surgeons , New York, United States
Correspondence  Leslie L Davidson ,Email: lld1@cumc.columbia.edu
Received: Jan 18, 2022  Accepted after revision: Apr 5, 2022
The Asenze cohort is set in South Africa, a middle-income country impacted by one of the highest global rates of people living with HIV/AIDS and high levels of socio-economic inequality. This longitudinal population-based cohort of children and their primary caregivers assesses household and caregiver functioning, child health, social well-being, and neuro-development from childhood through adolescence.
Almost 1600 children born at the peak of the HIV epidemic (2003-2005) were followed (with their primary caregivers) in three waves, between 2008 and 2021, at average ages five, seven, and 16. Wave 3 is currently underway having assessed over 1100 of the original Wave 1 children. Wave 4 begins in 2022.
The study, with a dyadic structure, uses a broad range of measures, validated in South Africa or recommended for global use, that address physical, social and neuro-development in childhood and adolescence, and the social, health and psychological status of their primary caregivers.
The Asenze study deepens understanding of childhood physical, cognitive, and social abilities and/or disabilities, including risk-taking behaviors, and biological, environmental, and social determinants of health. We anticipate the findings will contribute to the development of community-informed interventions to promote wellbeing in this South African population and elsewhere.
Keywords: Population-based cohort; Low-and-Middle Income Country; South Africa; HIV/AIDS; Child and Adolescent Health; Child and Adolescent Development
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